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January 11, 2019January 11, 2019

Mitochondrial Surveillance Mechanism Is Critical for Genomic Stability, Study Shows

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A natural RNA surveillance mechanism is crucial to maintain the integrity of mitochondria’s encoded information for protein production and prevent the accumulation of potential disease-causing molecules. The study, “Human ... Read more

January 4, 2019January 4, 2019

AOX Enzyme May Alleviate Symptoms of Mitochondrial Disease, Mouse Study Shows

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Researchers found an enzyme called alternative oxidase (AOX) that is able to bypass part of the mitochondrial respiratory chain (MRC) and alleviate symptoms of mitochondrial cardiomyopathy in a mouse ... Read more

December 21, 2018December 21, 2018

Entrada Raises $59M to Advance Program to Treat Rare, Deadly Mitochondrial Disease

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Entrada Therapeutics has raised $59 million in Series A financing to advance its intracellular enzyme replacement therapy program for treatment of a rare and deadly mitochondrial disease. Series A financing ... Read more

December 21, 2018December 21, 2018

Rising Healthcare Costs Strain EU Budgets Even as New Therapies Flourish

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Cash-strapped governments across the 28-member European Union are struggling to control runaway healthcare expenditures — at exactly the same time as the promise of new but expensive therapies to ... Read more

December 14, 2018December 14, 2018

GS010 Improves Visual Acuity, Quality of Life in LHON Patients, Phase 3 Trial Shows

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GS010, a gene therapy developed by GenSight Biologics, improves visual acuity and quality of life in patients with Leber hereditary optic neuropathy (LHON), a rare genetic mitochondrial disease that causes ... Read more

December 7, 2018December 7, 2018

NeuroVive Secures Funding to Advance NV354 for Potential Mitochondrial Disease Treatment

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Swedish innovation agency Vinnova has awarded $166,252 (1.5 million kroner) to NeuroVive Pharmaceuticals for the preclinical development and large-scale manufacture of its therapeutic candidate NV354 for mitochondrial diseases. The funds ... Read more

November 30, 2018November 30, 2018

Mitochondrial DNA from Fathers Could Lead to New Therapies, Study Suggests

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A new study found rare cases of mitochondrial DNA (mtDNA) being passed down from fathers in three unrelated families. The surprising findings could lead to novel treatments for inherited ... Read more

November 16, 2018November 16, 2018

Correcting Precise RNA Alterations May Restore Protein Production in MERRF, Study Suggests

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Restoring a missing transfer RNA (tRNA) modification improved protein production and stability in mitochondria — the cell’s power plants — in a patient with myoclonic epilepsy with ragged red fibers ... Read more

November 9, 2018November 9, 2018

Mount Sinai’s Icahn School of Medicine Cited for Commitment to Mitochondrial Care

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Owing to its commitment to mitochondrial medicine, the Icahn School of Medicine at Mount Sinai has been designated a certified Mitochondrial Medicine Center by the Mitochondrial Care Network (MCN). ... Read more

November 2, 2018November 2, 2018

New Mutations in NDUFA6 Gene Found in Four Cases of Mitochondrial Dysfunction

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New mutations affecting the NDUFA6 gene were identified as the cause of early-onset severe mitochondrial disorder in four unrelated children, a report shows. The study, “Bi-allelic Mutations in NDUFA6 ... Read more

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