Posts by: Patricia Inacio, PhD

Patricia Inacio, PhD

August 24, 2018August 24, 2018

Short-Term Treatment With KH176 Lessens Depression, Improves Mood in Mitochondria Patients, Study Shows

News

Short-term treatment with oral KH176 was safe and well-tolerated by mitochondria disease patients, and lessened their symptoms of depression while also having a positive effect in alertness and mood, ... Read more

July 20, 2018July 20, 2018

HotSpot Therapeutics Secures $45M to Advance Drug Discovery Platform

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HotSpot Therapeutics has secured $45 million to advance its drug discovery strategy that identifies so-called “hot spots” in proteins, allowing for their precise targeted regulation. Using this technology, HotSpot Therapeutics ... Read more

June 15, 2018June 15, 2018

Mutations in Mitochondrial Gene ANT1 Linked to Risk of Bipolar Disease in Mouse Study

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Mutations in the mitochondrial gene ANT1 may increase the risk of bipolar disease by altering levels of serotonin transmission in the brain, a mouse study suggests. The study, “Ant1 mutant mice ... Read more

March 26, 2018March 26, 2018

Gene Mutation Leads to Early Childhood Neurodegenerative Disorder, Researchers Find

News

Researchers found that inherited mutations in the PMPCB gene lead to a wide range of impairments in mitochondria and cause a form of early childhood neurodegenerative disorder in members of ... Read more

March 19, 2018March 19, 2018

New Cellular Pathway Helps Protect Mitochondria During Stress, Study Shows

News

A specific branch of cells’ stress-response pathway called unfolded protein response (UPR) may help protect mitochondria, new research shows. This finding suggests that controlling this particular branch may help ... Read more

March 2, 2018March 5, 2018

New Method Improves Delivery of Healthy Mitochondria To Cells Where It Is Dysfunctional, Study Shows

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South Korean researchers have developed a simple way to deliver healthy mitochondria to cells where it is dysfunctional, rescuing the cells’ energy levels and metabolic function. The study, “Delivery ... Read more

February 19, 2018

Manganese Deficiency Underlies Mitochondria Defects in Leigh Syndrome, Other Diseases, Study Finds

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Mutations in the SLC39A8 gene contribute to mitochondria impairments seen in Leigh syndrome by reducing the levels of manganese, a key element that protects against oxidative stress, researchers found. ... Read more

February 5, 2018

Blocking Accumulation of Stress Protein in Mitochondria May Halt PAH Progression, Study Suggests

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The accumulation of the stress-responsive heat shock protein 90 (HSP90) in the mitochondria of certain lung cells is a hallmark of pulmonary arterial hypertension (PAH), and inhibiting HSP90 reversed ... Read more

January 29, 2018January 29, 2018

Compound Mimicking Coenzyme Q10 May Help Protect Neuronal Mitochondria, Study Suggests

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An analog that mimics mitochondrial protein called coenzyme Q10 (CoQ10) has been found to protect neuronal mitochondria from the damaging effects of protein aggregates seen in Alzheimer’s disease. The ... Read more

December 22, 2017December 22, 2017

Genetic Background Influences Number of Mitochondrial Disease-Causing Mutations in Groups of People, Study Says

News

The rate of disease-causing mutations in mitochondrial DNA depends on the ethnic background and age of a specific population, researchers report. Disease-causing mutations were lower in European populations and ... Read more

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