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September 7, 2018September 7, 2018

$4M Grant Will Help Advance Research into NVP015 Treatment for Genetic Mitochondrial Disease

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The U.S. Department of Defense (DoD) has awarded a $4 million, three-year grant to the Children’s Hospital of Philadelphia (CHOP) to advance NeuroVive Pharmaceutical AB‘s NVP015 program for genetic ... Read more

August 31, 2018August 31, 2018

Investigational Therapy Jotrol Shows Potential to Treat Mitochondrial Disorders, Mouse Study Suggests

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Jotrol, Jupiter Orphan Therapeutics’ lead therapeutic candidate, was found to markedly improve mitochondria production in the liver and brain of mice with Alzheimer’s disease, according to preclinical data. These recent ... Read more

August 24, 2018August 24, 2018

Short-Term Treatment With KH176 Lessens Depression, Improves Mood in Mitochondria Patients, Study Shows

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Short-term treatment with oral KH176 was safe and well-tolerated by mitochondria disease patients, and lessened their symptoms of depression while also having a positive effect in alertness and mood, ... Read more

August 17, 2018August 17, 2018

Patients Groups Funding Research Project Focused on Developing New Nucleoside Therapy

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The Mito Foundation and The Lily Foundation are joining efforts to support the development of a nucleoside therapy to treat mitochondrial depletion syndromes. This announcement from the two patients groups ... Read more

August 10, 2018August 10, 2018

Women with Mitochondrial Disease More Prone to Pregnancy Complications, Study Shows

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Women with mitochondrial disease or mitochondrial dysfunction are more susceptible to complications during pregnancy, and their newborns are more likely to have congenital defects, a retrospective study shows. The study, ... Read more

July 27, 2018July 27, 2018

SLC25A4 Gene Mutation Linked to Mild Mitochondrial Myopathy in Children, Case Study Shows

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A new mutation identified in the SLC25A4 gene has been linked to childhood-onset mild myopathy (muscle disease) in a case study from the Children’s Hospital of Philadelphia (CHOP). The ... Read more

July 20, 2018July 20, 2018

HotSpot Therapeutics Secures $45M to Advance Drug Discovery Platform

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HotSpot Therapeutics has secured $45 million to advance its drug discovery strategy that identifies so-called “hot spots” in proteins, allowing for their precise targeted regulation. Using this technology, HotSpot Therapeutics ... Read more

July 13, 2018July 13, 2018

Cerebrospinal Fluid Biomarker NfL Can Help Monitor Nerve Cell Degeneration, Study Says

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Analysis of a cerebrospinal fluid protein called neurofilament light (NfL), which is linked to nerve cell damage, can help monitor the neurodegenerative process in patients with mitochondrial diseases. This ... Read more

July 6, 2018July 6, 2018

NeuroVive Licenses BridgeBio Subsidiary to Develop LHON Therapies

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BridgeBio Pharma has entered into an exclusive licensing agreement with NeuroVive Pharmaceutical AB for the development of a subset of chemical compounds under NeuroVive’s NVP015 program. The goal is to further ... Read more

June 29, 2018June 29, 2018

Older Moms More Likely to Pass Along Mitochondrial DNA with Mutations, Study Finds

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A mathematical model that can predict the nature of the mitochondrial DNA a child will inherit from its mother was part of a study that also found that maternal ... Read more

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