Abnormal Protein Interaction Impairs Mitochondrial Function, May Lead to Neurodegenerative Disorders, Study Suggests

The normal interaction between two key members of the same mitochondrial protein family is essential to maintain proper energy production and prevent oxidative damage associated with neurodegenerative diseases, Wayne State University researchers have found. The study titled “The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2):…

Hypoxia May Protect Human Brains Against Leigh Syndrome, Mice Study Suggests

Low levels of oxygen, or hypoxia, may prevent and even reverse brain lesions associated with Leigh syndrome, a mitochondrial disease. The study, “Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome,” appeared in the journal PNAS. Leigh syndrome is a rare genetic disorder linked to mutations…

Mitochondria Transplants Ease Hypoxia-induced Pulmonary Hypertension in Animal Study

Mitochondrial transplants may prevent or ease hypoxia-induced pulmonary hypertension, according to a study developed at Huazhong University of Science and Technology in China. The study, “Mitochondrial transplantation attenuates hypoxic pulmonary hypertension,” published in the journal Oncotarget, took advantage of the different mitochondrial responses to hypoxia (low oxygen levels) in…