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In the pipeline at Stealth BioTherapeutics is a new therapy, MTP-131, with the potential to treat individuals with mitochondrial disease and other diseases affected by mitochondrial dysfunction. The systemic version of MTP-131 (also known as Bendavia) is in clinical trials for skeletal muscle and cardio-renal diseases. The topical…
Throughout 2015, Mitochondrial Disease News reported on studies into therapies, insights into the mechanisms underlying mitochondrial diseases, and related events. As the year comes to an end, here are the 10 articles most viewed by Mitochondrial Disease News readers, each with a brief summary of the developments that made them of such…
NuSirt Biopharma, a company focused on therapies for chronic metabolic diseases, recently announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to the company’s development program to treat non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD). Mitochondrial dysfunction in the liver plays a key…
MitoQ, the first antioxidant formula able to penetrate mitochondria and deliver antioxidants at meaningful levels, has been selected for an internationally renowned anti-aging test known as the Intervention Testing Program (ITP) and run by the National Institute on Aging (NIA), a branch of the U.S. National Institutes of Health. MitoQ is a synthetic antioxidant,…
ChromaDex Corp., a company dedicated to technologies in wellness, health, dietary/nutrition supplements, skin care and pharmaceuticals, recently announced a Materials Cooperative Research and Development Agreement (MCRADA) over the company’s product NIAGEN with the National Institute on Aging (NIA), part of the National Institutes of Health (NIH). NIAGEN is…
A new study suggested a novel physiological role for mitochondria. Researchers found that mitochondrial dysfunction in proliferating human cells induces senescence (biological aging) and causes a distinct secretory phenotype. The research study results, which might have great importance for the study of mitochondrial diseases and age-related conditions such as Parkinson’s,…
A study recently published in the journal Cell Reports revealed the mechanism by which a benign kidney tumor can develop into an aggressive cancer, and the role mitochondria dysfunction has on this process. The study, titled “The Genomic Landscape of Renal Oncocytoma Identifies a…
In a new study, researchers linked the protein YME1 with a proper mitochondrial function and its absence to the fragmentation of mitochondria in vivo, dysfunction of mitochondrial activity, and the consequent onset of dilated cardiomyopathy in mice. The researchers also showed that dietary changes can restore proper heart function. The research study, titled…
A team of researchers have designed a new method to determine, in a rapid and apparently accurate way, the morphology of mitochondria in cells using a microscope. Through this method, called Flicker-assisted Localization Microscopy (FaLM), researchers discovered that in vivo models of hypertension are characterized by larger mitochondria, occupying more of…
According to a new study published in the journal Proceedings of the National Academy of Sciences, mitochondria may play a previously unknown role in mind-body interactions. The findings, based on new investigations into stress responses, may carry implications for the biology of psychiatric and neurological diseases, as well as…
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