Magdalena Kegel,  —

A recent study in the Journal of the American Heart Association showed that mice fed a high-fat, high-sucrose (HFHS) diet developed metabolic heart disease through the induction of changes in mitochondrial enzymes by reactive oxygen species (ROS). Earlier studies in HFHS-fed mice suggested that ROS are involved in the…

Researchers from the Salk Institute have unraveled molecular mechanisms behind mitochondrial fragmentation and re-assembly, a cellular mechanism that maintains healthy energy levels and protects cells from insults. The findings may have implications for disorders like mitochondrial disease, diabetes, cancer, and neurodegenerative diseases linked to dysfunctional mitochondria. When mitochondria are subjected…

A new study has identified mitochondrial dysfunction in satellite cells — a type of muscle stem cells — as a possible reason for the muscle weakness that often follows sepsis. The study, published in the journal Nature Communications, also found a way to rescue mitochondrial dysfunction related to sepsis, restoring…