Compound Mimicking Coenzyme Q10 May Help Protect Neuronal Mitochondria, Study Suggests

Compound Mimicking Coenzyme Q10 May Help Protect Neuronal Mitochondria, Study Suggests

An analog that mimics mitochondrial protein called coenzyme Q10 (CoQ10) has been found to protect neuronal mitochondria from the damaging effects of protein aggregates seen in Alzheimer’s disease. The compound, developed by researchers at Arizona State University, may help researchers prevent the toxic effects of amyloid beta aggregates in the brain.

The study, “Oligomeric amyloid beta preferentially targets neuronal and not glial mitochondrial-encoded mRNAs,” was published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

Poor functioning of small organelles known as mitochondria — the powerhouses of cells — is an early event in Alzheimer’s disease. Preclinical studies have shown that the accumulation of both amyloid beta and oligomeric amyloid beta, the small aggregates of amyloid protein commonly found in the brain with Alzheimer’s disease, were toxic to mitochondria. This suggests that these molecules may contribute to the metabolic deficits observed in Alzheimer’s disease, researchers wrote.

“Mitochondria are the major source of energy in brain cells, and deficiencies in energy metabolism have been shown to be one of the earliest events in Alzheimer’s disease pathobiology,” Diego Mastroeni, the study’s lead author and a scientist at the ASU-Banner Neurodegenerative Disease Research Center, said in a press release.

Researchers first isolated a type of neurons, called pyramidal cells, from the hippocampus of Alzheimer’s patients who had succumbed to the disease. They found that compared to cells from non-diseased controls, the pyramidal cells showed a marked decrease in expression of several mitochondrial genes.

A similar level of decrease also was detected in vitro when researchers exposed cells from a human neuroblastoma line (cancer cells from nerve tissue) to oligomeric amyloid beta, revealing the detrimental effects of oligomeric amyloid beta on the mitochondria of neurons.

The team then pretreated the human brain cells with a compound it designed to mimic the action of a natural component within mitochondria, CoQ10. CoQ10 protects and helps boost mitochondria energy production.

The results showed that pretreating the neuron cells with the CoQ10 analog protects the mitochondria from the effects of oligomeric amyloid beta, “providing an effective pretreatment option to prevent OAb toxicity,” they wrote.

“This study reinforces the toxicity of oligomeric amyloid beta on neuronal mitochondria and stresses the importance for protective compounds to protect the mitochondria from oligomeric amyloid beta toxicity,” Mastroeni said.

The team also noted that these findings offer “the opportunity for more precise (cell-type specific) elucidation of molecular events in Alzheimer’s disease that lead to mitochondrial dysfunction.”

One comment

  1. Let’s read the following two sentences: “Poor functioning of small organelles known as mitochondria — the powerhouses of cells — is an early event in Alzheimer’s disease”.
    “The team then pretreated the human brain cells with a compound it designed to mimic the action of a natural component within mitochondria, CoQ10. CoQ10 protects and helps boost mitochondria energy production”.
    We must proceed with order. Firstly, Co Q10 plays a central role in the physiological function of the mitochondrial respiratory chain, as I have shown, from the clinical view-point, 25 years ago (1-7). As a consequence, a compound mimicking Co Q10 may be useful in normalizing impaired mitochondria.
    Secondly, I have demonstrated and described the AD Inherited Real Risk bedside recognized with a stethoscope from birth , and eliminated with Reconstructing Mitochondrial Quantum Therapy (8-10). As a consequence the small aggregates of amyloid protein commonly found in the brain with Alzheimer’s disease,toxic to mitochondria, may worsen mitochondrial impairment but not cause it.

    References
    1)Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia ipolipidemmizante diagnosticata con la Percussione Ascoltata. Settimana Italiana di Dietologia, 9-13 Aprile 1991, Merano. Atti, pg. 65. Epat. 37, 17,1990.
    2)Stagnaro-Neri M., Stagnaro S., Acidi grassi W-3, scavengers dei radicali liberi e attivatori del ciclo Q della sintesi del Co Q10. Gazz. Med. It. – Arch. Sc. Med. 151, 341, 1992.
    3)Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-ascoltatoria da carenza di Co Q10. Medic. Geriatr. XXIV, 239, 1993,
    4) Stagnaro-Neri M., Stagnaro S., Il Co Q10 nella prevenzione e nella terapia dell’osteoporosi primitiva. Clin.Terap.146, 215-219, 1993 [Medline]
    5) Stagnaro-Neri M, Stagnaro S. Co Q10 in the prevention and treatment of primary osteoporosis. Preliminary data. Clin Ter.;146(3):215-9, 1995 [MEDLINE]
    6) Stagnaro Sergio. Pivotal Role Of Co Q10 In Processes Of Aging. Medical News Today, 27 Nov 2008 at 7:57 am http://www.medicalnewstoday.com/youropinions.php?opinionid=34681
    7)Sergio Stagnaro. Functional Decline in Aging and Co Q10 Deficiency Syndrome.30 March, 2011. http://www.sci-vox.com, http://www.sci-vox.com/stories/story/2011-03-30functional+decline+in+aging+and+co+q10+deficiency+syndrome.html
    8) Marco Marchionni, Simone Caramel, Sergio Stagnaro (2013). Inherited Real Risk of Alzheimer’s Disease: bedside diagnosis and primary prevention.Frontiers in Neuroscience, in http://www.frontiersin.org/Aging_Neuroscience/10.3389/fnagi.2013.00013/full
    9)Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/article/10.1007/s12603-013-0435-7 [Medline].
    10) Sergio Stagnaro. Il Segno di Scopinaro: un pizzicotto cutaneo permette in 3 secondi di fare la Diagnosi Differenziale tra Malattia di Alzheimer e Demenza Senile.
    http://www.sisbq.org/uploads/5/6/8/7/5687930/segnodiscopinaro.pdf

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