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Myofibrillar Myopathies Characterized by Mitochondrial Dysfunction

Muscle disorders (myofibrillar myopathies) can sometimes be caused by genetic mutations in genes related to proteins in muscle bands, but other times, myofibrillar myopathies are caused by mitochondrial dysfunction. According to a research team from the Departments of Neurology and Pathology at Technische Universität Dresden in Germany, different subtypes of…

Reata Enrolls First Patient in RTA 408 Trial for Mitochondrial Myopathies

Irving, Texas-based Reata Pharmaceuticals has just announced the enrollment of the first patient in the company’s Phase II MOTOR clinical trial. This study will seek to determine the safety, tolerability and efficacy of Reata’s experimental RTA 408 Oral Capsules as a potential treatment for mitochondrial myopathies (MM). RTA-408 works to improve mitochondrial…

Fat Intake Through Diet Could Ease Mitochondrial Disease

Researchers have discovered a specific genetic mutation responsible for a mitochondrial disease observed in mice that quickly ages nine month-old specimens that present with osteoporosis, thinning grey hair, infertility, poor hearing, heart problems and lost weight. The mice carry this disease from birth, but researchers have also found that some harness a “secret weapon” that temporarily…