Author Archives: Joana Fernandes, PhD

Protein Linked to Mitochondrial Dysfunction Speeds Up Age-related Eye Disorders in Mice

Mutations in a protein called Tmem135 leads to disrupted mitochondrial activity and accelerates the progression of visual deficiencies, according to a new study. The paper, “Mouse Tmem135 Mutation Reveals A Mechanism Involving Mitochondrial Dynamics Leading To Age-Dependent Retinal Pathologies,” was published in the journal eLife. “Age-related macular degeneration…

Distinguishing Between Primary and Secondary Mitochondrial Disease Important for Diagnosis, Treatment

A recent review highlights the latest findings in mitochondrial disease and the importance of distinguishing between primary mitochondrial disease (PMD) and secondary mitochondrial disease (SMD) in the diagnosis of patients, as treatments and outcome may be very different for these two cases. The study, “Primary Mitochondrial Disease and Secondary Mitochondrial…